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Research Article

Differential Use of Signal Peptides and Membrane Domains Is a Common Occurrence in the Protein Output of Transcriptional Units

  • Melissa J Davis,

    Affiliation: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia

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  • Kelly A Hanson,

    Affiliation: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia

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  • Francis Clark,

    Affiliations: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia, Advanced Computational Modeling Centre, University of Queensland, St. Lucia, Queensland, Australia

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  • J. Lynn Fink,

    Affiliation: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia

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  • Fasheng Zhang,

    Affiliation: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia

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  • Takeya Kasukawa,

    Affiliation: Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan

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  • Chikatoshi Kai,

    Affiliation: Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan

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  • Jun Kawai,

    Affiliations: Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Piero Carninci,

    Affiliations: Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Yoshihide Hayashizaki,

    Affiliations: Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan, Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

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  • Rohan D Teasdale mail

    To whom correspondence should be addressed. E-mail: R.Teasdale@imb.uq.edu.au

    Affiliation: Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia

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  • Published: April 28, 2006
  • DOI: 10.1371/journal.pgen.0020046
  • Featured in PLOS Collections

About the Authors

Melissa J Davis, Kelly A Hanson, Francis Clark, J. Lynn Fink, Fasheng Zhang, Rohan D Teasdale
Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St. Lucia, Queensland, Australia
Francis Clark
Advanced Computational Modeling Centre, University of Queensland, St. Lucia, Queensland, Australia
Takeya Kasukawa, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki
Genome Exploration Research Group (Genome Network Project Core Group), RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, Yokohama, Japan
Jun Kawai, Piero Carninci, Yoshihide Hayashizaki
Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan

Corresponding Author

Email: R.Teasdale@imb.uq.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MJD, KAH, FC, PC, YH, and RDT conceived and designed the experiments. MJD, FC, and CK performed the experiments. MJD, KAH, FC, and RDT analyzed the data. MJD, KAH, FC, JLF, FZ, TK, CK, JK, PC, and YH contributed reagents/materials/analysis tools. KAH and JLF provided advice on methodology. MJD, FC, and RDT wrote the paper.