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Research Article

Pol II–Expressed shRNA Knocks Down Sod2 Gene Expression and Causes Phenotypes of the Gene Knockout in Mice

  • Xu-Gang Xia equal contributor,

    equal contributor Contributed equally to this work with: Xu-Gang Xia, Hongxia Zhou

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Hongxia Zhou equal contributor,

    equal contributor Contributed equally to this work with: Xu-Gang Xia, Hongxia Zhou

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Enrique Samper,

    Affiliation: Buck Institute for Age Research, Novato, California, United States of America

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  • Simon Melov,

    Affiliation: Buck Institute for Age Research, Novato, California, United States of America

    X
  • Zuoshang Xu mail

    To whom correspondence should be addressed. E-mail: zuoshang.xu@umassmed.edu

    Affiliations: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: January 27, 2006
  • DOI: 10.1371/journal.pgen.0020010

About the Authors

Xu-Gang Xia, Hongxia Zhou, Zuoshang Xu
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Enrique Samper, Simon Melov
Buck Institute for Age Research, Novato, California, United States of America
Zuoshang Xu
Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Zuoshang Xu
Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: zuoshang.xu@umassmed.edu

Competing Interests

XGX, HZ, and ZX are authors of a pending patent on the Pol II–shRNA construct used in this study.

Author Contributions

XGX, HZ, and ZX conceived and designed the experiments. XGX, HZ, ES, and SM performed the experiments. XGX, HZ, ES, SM, and ZX analyzed the data. XGX, HZ, ES, and SM contributed reagents/materials/analysis tools. ZX wrote the paper.