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Research Article

Differential Susceptibility to Hypertension Is Due to Selection during the Out-of-Africa Expansion

  • J. Hunter Young mail,

    To whom correspondence should be addressed. E-mail: jhyoung@jhmi.edu

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Yen-Pei C Chang,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • James Dae-Ok Kim,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Jean-Paul Chretien,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Michael J Klag,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Michael A Levine,

    Affiliation: Division of Pediatrics, The Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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  • Christopher B Ruff,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Nae-Yuh Wang,

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Aravinda Chakravarti

    Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: December 30, 2005
  • DOI: 10.1371/journal.pgen.0010082

About the Authors

J. Hunter Young, Yen-Pei C Chang, James Dae-Ok Kim, Jean-Paul Chretien, Michael J Klag, Christopher B Ruff, Nae-Yuh Wang, Aravinda Chakravarti
The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Michael A Levine
Division of Pediatrics, The Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

Corresponding Author

Email: jhyoung@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JHY, YPCC, and AC conceived and designed the experiments. JHY and YPCC performed the experiments. JHY, YPCC, JDOK, JPC, and NYW analyzed the data. JHY, YPCC, MJK, MAL, CBR, NYW, and AC wrote the paper.