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Research Article

Positive Selection of a Pre-Expansion CAG Repeat of the Human SCA2 Gene

  • Fuli Yu,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Pardis C Sabeti,

    Affiliation: Broad Institute of the Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America

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  • Paul Hardenbol,

    Affiliation: ParAllele Bioscience, South San Francisco, California, United States of America

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  • Qing Fu,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ben Fry,

    Affiliation: Broad Institute of the Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America

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  • Xiuhua Lu,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Sy Ghose,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Richard Vega,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ag Perez,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Shiran Pasternak,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Suzanne M Leal,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Thomas D Willis,

    Affiliation: ParAllele Bioscience, South San Francisco, California, United States of America

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  • David L Nelson,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • John Belmont,

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Richard A Gibbs mail

    To whom correspondence should be addressed. E-mail: agibbs@bcm.tmc.edu

    Affiliation: Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Published: September 30, 2005
  • DOI: 10.1371/journal.pgen.0010041

About the Authors

Fuli Yu, Qing Fu, Xiuhua Lu, Sy Ghose, Richard Vega, Ag Perez, Shiran Pasternak, Suzanne M Leal, David L Nelson, John Belmont, Richard A Gibbs
Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America
Pardis C Sabeti, Ben Fry
Broad Institute of the Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America
Paul Hardenbol, Thomas D Willis
ParAllele Bioscience, South San Francisco, California, United States of America

Corresponding Author

Email: agibbs@bcm.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

FY, PCS, JB, and RAG conceived and designed the experiments. FY, QF, XL, SG, RV, and AP performed the experiments. FY, PCS, PH, SP, and SML analyzed the data. PCS, PH, BF, and TDW contributed reagents/materials/analysis tools. FY, DLN, JB, and RAG wrote the paper.