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Research Article

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency

  • Stacie K Loftus mail,

    To whom correspondence should be addressed. E-mail: sloftus@mail.nih.gov.

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jennifer L Cannons,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Arturo Incao,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Evgenia Pak,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Amy Chen,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Patricia M Zerfas,

    Affiliation: Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Mark A Bryant,

    Affiliation: Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Leslie G Biesecker,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Pamela L Schwartzberg,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • William J Pavan

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: September 23, 2005
  • DOI: 10.1371/journal.pgen.0010038

About the Authors

Stacie K Loftus, Jennifer L Cannons, Arturo Incao, Evgenia Pak, Amy Chen, Leslie G Biesecker, Pamela L Schwartzberg, William J Pavan
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Patricia M Zerfas, Mark A Bryant
Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: sloftus@mail.nih.gov.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SKL, LGB, PLS, and WJP conceived and designed the experiments. SKL, JLC, AI, EP, AC, PMZ, and MAB performed the experiments. SKL, JLC, AI, EP, AC, PMZ, MAB, LGB, PLS, and WJP analyzed the data. SKL, JLC, EP, AC, PMZ, MAB, and PLS contributed reagents/materials/analysis tools. SKL, JLC, PMZ, MAB, LGB, PLS, and WJP wrote the paper.