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Research Article

Fog2 Is Required for Normal Diaphragm and Lung Development in Mice and Humans

  • Kate G Ackerman mail,

    To whom correspondence should be addressed. E-mail: kackerman@rics.bwh.harvard.edu

    Affiliations: Division of Emergency Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Divison of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Bruce J Herron,

    Affiliation: Genomics Institute, Wadsworth Center, Troy, New York, United States of America

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  • Sara O Vargas,

    Affiliation: Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Hailu Huang,

    Affiliation: Divison of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sergei G Tevosian,

    Affiliation: Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Lazaros Kochilas,

    Affiliation: Department of Pediatrics, Brown Medical School, Providence, Rhode Island, United States of America

    X
  • Cherie Rao,

    Affiliation: Divison of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Barbara R Pober,

    Affiliation: Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Randal P Babiuk,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

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  • Jonathan A Epstein,

    Affiliation: Cardiovascular Division, Department of Medicine and Department of Cell and Molecular Biology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America

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  • John J Greer,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

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  • David R Beier

    Affiliation: Divison of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 17, 2005
  • DOI: 10.1371/journal.pgen.0010010

About the Authors

Kate G Ackerman
Division of Emergency Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Kate G Ackerman, Hailu Huang, Cherie Rao, David R Beier
Divison of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Bruce J Herron
Genomics Institute, Wadsworth Center, Troy, New York, United States of America
Sara O Vargas
Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Sergei G Tevosian
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, United States of America
Lazaros Kochilas
Department of Pediatrics, Brown Medical School, Providence, Rhode Island, United States of America
Barbara R Pober
Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Randal P Babiuk, John J Greer
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
Jonathan A Epstein
Cardiovascular Division, Department of Medicine and Department of Cell and Molecular Biology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: kackerman@rics.bwh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KGA, JJG, and DRB conceived and designed the experiments. KGA, BJH, HH, SGT, LK, CR, RPB, and JAE performed the experiments. KGA, BJH, HH, LK, CR, JAE, JJG, and DRB analyzed the data. KGA, SOV, SGT, BRP, JAE, JJG, and DRB contributed reagents/materials/analysis tools. KGA and DRB wrote the paper.