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Research Article

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

  • Patricia L. M Dahia mail,

    To whom correspondence should be addressed. E-mail: Patricia_Dahia@dfci.harvard.edu

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

    ¤Current address: Department of Medicine and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America

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  • Ken N Ross,

    Affiliation: Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Matthew E Wright,

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • César Y Hayashida,

    Affiliation: University of São Paulo School of Medicine, São Paulo, Brazil

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  • Sandro Santagata,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Marta Barontini,

    Affiliation: Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina

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  • Andrew L Kung,

    Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gabriela Sanso,

    Affiliation: Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina

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  • James F Powers,

    Affiliation: Tufts–New England Medical Center, Boston, Massachusetts, United States of America

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  • Arthur S Tischler,

    Affiliation: Tufts–New England Medical Center, Boston, Massachusetts, United States of America

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  • Richard Hodin,

    Affiliation: Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Shannon Heitritter,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Francis Moore Jr.,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Robert Dluhy,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Julie Ann Sosa,

    Affiliation: Yale University, New Haven, Connecticut, United States of America

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  • I. Tolgay Ocal,

    Affiliation: Yale University, New Haven, Connecticut, United States of America

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  • Diana E Benn,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Deborah J Marsh,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Bruce G Robinson,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Katherine Schneider,

    Affiliation: Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Judy Garber,

    Affiliation: Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Seth M Arum,

    Affiliation: Boston Medical Center, Boston, Massachusetts, United States of America

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  • Márta Korbonits,

    Affiliation: St. Bartholomew's Hospital, London, United Kingdom

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  • Ashley Grossman,

    Affiliation: St. Bartholomew's Hospital, London, United Kingdom

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  • Pascal Pigny,

    Affiliation: Regional University Hospital, Lille, France

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  • Sérgio P. A Toledo,

    Affiliation: University of São Paulo School of Medicine, São Paulo, Brazil

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  • Vania Nosé,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Cheng Li,

    Affiliation: Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Charles D Stiles

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 25, 2005
  • DOI: 10.1371/journal.pgen.0010008

About the Authors

Patricia L. M Dahia, Matthew E Wright, Charles D Stiles
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Ken N Ross
Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
César Y Hayashida, Sérgio P. A Toledo
University of São Paulo School of Medicine, São Paulo, Brazil
Sandro Santagata, Shannon Heitritter, Francis Moore Jr., Robert Dluhy, Vania Nosé
Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Marta Barontini, Gabriela Sanso
Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina
Andrew L Kung
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
James F Powers, Arthur S Tischler
Tufts–New England Medical Center, Boston, Massachusetts, United States of America
Richard Hodin
Massachusetts General Hospital, Boston, Massachusetts, United States of America
Julie Ann Sosa, I. Tolgay Ocal
Yale University, New Haven, Connecticut, United States of America
Diana E Benn, Deborah J Marsh, Bruce G Robinson
Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia
Katherine Schneider, Judy Garber
Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Seth M Arum
Boston Medical Center, Boston, Massachusetts, United States of America
Márta Korbonits, Ashley Grossman
St. Bartholomew's Hospital, London, United Kingdom
Pascal Pigny
Regional University Hospital, Lille, France
Cheng Li
Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: Patricia_Dahia@dfci.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PLMD and CDS conceived and designed the experiments. PLMD, KNR, MEW, SS, VN, and CL performed the experiments. PLMD, KNR, SS, VN, and CL analyzed the data. PLMD, CYH, MB, ALK, GS, JFP, AST, RH, SH, FM, RD, JAS, ITO, DEB, DJM, BGR, KS, JG, SMA, MK, AG, PP, and SPAT contributed reagents/materials/analysis tools. PLMD and CDS wrote the paper.