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Research Article

Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C Disease

  • Dennis C Ko,

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ljiljana Milenkovic,

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Steven M Beier,

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Hermogenes Manuel,

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • JoAnn Buchanan,

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Matthew P Scott mail

    To whom correspondence should be addressed. E-mail: mscott@stanford.edu

    Affiliation: Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: July 25, 2005
  • DOI: 10.1371/journal.pgen.0010007

About the Authors

Dennis C Ko, Ljiljana Milenkovic, Steven M Beier, Hermogenes Manuel, JoAnn Buchanan, Matthew P Scott
Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: mscott@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DCK, LM, SMB, and MPS conceived and designed the experiments. DCK, LM, HM, and JB performed the experiments. DCK analyzed the data. DCK, LM, SMB, HM, and JB contributed reagents/materials/analysis tools. DCK, LM, and MPS wrote the paper.