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Research Article

Pseudogenization of a Sweet-Receptor Gene Accounts for Cats' Indifference toward Sugar

  • Xia Li,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Weihua Li,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Hong Wang,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Jie Cao,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Kenji Maehashi,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

    ¤ Current address: Department of Fermentation Science, Tokyo University of Agriculture, Tokyo, Japan

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  • Liquan Huang,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Alexander A Bachmanov,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Danielle R Reed,

    Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America

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  • Véronique Legrand-Defretin,

    Affiliation: The WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire, United Kingdom

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  • Gary K Beauchamp,

    Affiliations: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America, Department of Psychology, School of Arts and Sciences and Department of Anatomy, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Joseph G Brand mail

    To whom correspondence should be addressed. E-mail: brand@monell.org

    Affiliations: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America, Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America

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  • Published: July 25, 2005
  • DOI: 10.1371/journal.pgen.0010003

About the Authors

Xia Li, Weihua Li, Hong Wang, Jie Cao, Kenji Maehashi, Liquan Huang, Alexander A Bachmanov, Danielle R Reed, Gary K Beauchamp, Joseph G Brand
Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America
Véronique Legrand-Defretin
The WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire, United Kingdom
Gary K Beauchamp
Department of Psychology, School of Arts and Sciences and Department of Anatomy, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Joseph G Brand
Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Joseph G Brand
Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: brand@monell.org

Competing Interests

HW, JC, KM, and LH declare that they have no competing interests of a financial, professional, or personal nature. VLD is an employee of the Masterfoods division of Mars. GKB is on an advisory board to the WALTHAM Centre. Patents describing the uses of the feline receptors have been filed, and name as inventors: XL, WL, JGB, DRR, and AAB.

Author Contributions

XL, LH, DRR, VLD, GKB, and JGB conceived and designed the experiments. XL, WL, HW, JC, KM, and JGB performed the experiments. XL, WL, JC, AAB, and DRR analyzed the data. XL, HW, LH, AAB, and JGB contributed reagents/materials/analysis tools. XL, AAB, DRR, GKB, and JGB wrote the paper.