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Research Article

Deletion Hotspots in AMACR Promoter CpG Island Are cis-Regulatory Elements Controlling the Gene Expression in the Colon

  • Xiang Zhang,

    Affiliations: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Irwin Leav,

    Affiliations: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Department of Pathology and Laboratory Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Monica P. Revelo,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

    Current address: Department of Pathology and Laboratory Medicine, University of Utah, Salt Lake City, Utah, United States of America

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  • Ranjan Deka,

    Affiliations: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Center for Genome Information, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Mario Medvedovic,

    Affiliations: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Zhong Jiang,

    Affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Shuk-Mei Ho mail

    shuk-mei.ho@uc.edu

    Affiliations: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Cancer Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Published: January 16, 2009
  • DOI: 10.1371/journal.pgen.1000334

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Posted by PLoS_Genetics on 29 Jan 2009 at 16:51 GMT