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Research Article

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

  • Bryan N. Howie,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

    Current address: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Peter Donnelly,

    Affiliations: Department of Statistics, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, United Kingdom

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  • Jonathan Marchini mail

    marchini@stats.ox.ac.uk

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • Published: June 19, 2009
  • DOI: 10.1371/journal.pgen.1000529

Reader Comments (4)

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Lowmem option in BEAGLE

Posted by SharonBrowning on 16 Jul 2009 at 14:29 GMT

BEAGLE includes an option to decrease memory usage, but this would come at the cost of increased running time.
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000529#article1.body1.sec3.sec2.sec6.p2

The low memory option for BEAGLE increases computing time by at most a factor of 2, so that even with this option BEAGLE will still be considerably faster than the most accurate competing methods.

No competing interests declared.