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Research Article

Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation

  • Emily E. Hare equal contributor,

    equal contributor Contributed equally to this work with: Emily E. Hare, Brant K. Peterson

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Brant K. Peterson equal contributor,

    equal contributor Contributed equally to this work with: Emily E. Hare, Brant K. Peterson

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Integrative Genomics, University of California Berkeley, Berkeley, California, United States of America

    X
  • Venky N. Iyer,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

    X
  • Rudolf Meier,

    Affiliation: Department of Biological Sciences, National University of Singapore, Singapore

    X
  • Michael B. Eisen mail

    mbeisen@lbl.gov

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Integrative Genomics, University of California Berkeley, Berkeley, California, United States of America, Genomics Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, California Institute for Quantitative Biosciences, Berkeley, California, United States of America

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  • Published: June 27, 2008
  • DOI: 10.1371/journal.pgen.1000106

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Links to two related articles

Posted by PLoS_Genetics on 20 Mar 2009 at 10:04 GMT

We have demonstrated here that complex animal regulatory sequences can tolerate nearly complete rearrangement of their transcription factor binding sites without appreciably altering their transcriptional output.
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000106#article1.body1.sec3.p1

- A Closer Look at the eve Stripe 2 Enhancers of Drosophila and Themira (http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000276)

- A Careful Look at Binding Site Reorganization in the even-skipped Enhancers of Drosophila and Sepsids (http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000268)

No competing interests declared.