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Research Article

Drosophila melanogaster Acetyl-CoA-Carboxylase Sustains a Fatty Acid–Dependent Remote Signal to Waterproof the Respiratory System

  • Jean-Philippe Parvy equal contributor,

    equal contributor Contributed equally to this work with: Jean-Philippe Parvy, Laura Napal

    Affiliations: CNRS, Centre de Génétique Moléculaire, UPR 3404, Gif-sur-Yvette, France, Université Pierre et Marie Curie- Paris 6, Paris, France

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  • Laura Napal equal contributor,

    equal contributor Contributed equally to this work with: Jean-Philippe Parvy, Laura Napal

    Affiliations: CNRS, Centre de Génétique Moléculaire, UPR 3404, Gif-sur-Yvette, France, Université Paris-Sud 11, Orsay, France

    Current address: Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Thomas Rubin,

    Affiliations: CNRS, Centre de Génétique Moléculaire, UPR 3404, Gif-sur-Yvette, France, Université Paris-Sud 11, Orsay, France

    Current address: CNRS UMR 3215/INSERM U-934, Institut Curie, Paris, France

    X
  • Mickael Poidevin,

    Affiliations: CNRS, Centre de Génétique Moléculaire, UPR 3404, Gif-sur-Yvette, France, Université Paris-Sud 11, Orsay, France

    X
  • Laurent Perrin,

    Affiliation: IBDML, Université de la Méditerranée, Marseille, France

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  • Claude Wicker-Thomas,

    Affiliation: CNRS, LEGS, UPR 9034, Gif-sur-Yvette, France

    X
  • Jacques Montagne mail

    montagne@cgm.cnrs-gif.fr

    Affiliations: CNRS, Centre de Génétique Moléculaire, UPR 3404, Gif-sur-Yvette, France, Université Paris-Sud 11, Orsay, France

    X
  • Published: August 30, 2012
  • DOI: 10.1371/journal.pgen.1002925

Reader Comments (1)

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an interesting and unexpected result - follow up insulin!

Posted by clementkent on 06 Sep 2012 at 00:31 GMT

The authors are to be congratulated on a very thorough paper with some interesting and unexpected findings about the role of oenocytes. I have a specific suggestion: that the role of the insulin system along with glycogen phosphorylase and GSK be further investigated. Differences in adult allocation of energy stores to triglycerides and glycogen were noted in Kent et al (2009) PLoS genetics 5 (8), e1000609 in backgrounds where alleles of the foraging gene (for) interacted with the insulin pathway. Paradoxically, in the same backgrounds larval energy store allocations varied in the opposite pattern (Kaun et al 2008, J Exp Biol 211, 3160-3166). The larval and adult oenocytes may behave differently; this would seem easy to investigate in the authors' set of fly constructs, and then to test whether Ins/Tor pathway interactions are essential to the switch from lipid storage to glycogen.

The results about the tracheae and hypoxia represent one of those amazing pleiotropic effects of genes that would not, I think, have been anticipated. Congratulations!

- Clement Kent

No competing interests declared.