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Research Article

How To Perform Meaningful Estimates of Genetic Effects

  • José M. Álvarez-Castro mail,

    jose.alvarez-castro@hgen.slu.se

    Affiliation: Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

    Current address: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

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  • Arnaud Le Rouzic,

    Affiliation: Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

    Current address: CEES, Department of Biology, Oslo University, Oslo, Norway

    X
  • Örjan Carlborg

    Affiliation: Linnaeus Centre for Bioinformatics, Uppsala University, Uppsala, Sweden

    Current address: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

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  • Published: May 02, 2008
  • DOI: 10.1371/journal.pgen.1000062

Reader Comments (3)

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A question on Equation (6)

Posted by jzma on 07 Oct 2010 at 06:02 GMT

It seems that Equation (6) is true only when the variance-covariance matrix of E_1 is diagonal. In general, the equation should be replaced by
Var(E_2)=T_12 Var(E_1) Transpose(T_12).
Is this correct?

BTW, the author's email address does not seem to be valid.

No competing interests declared.

RE: A question on Equation (6)

jm_alvarez-castro replied to jzma on 13 Oct 2010 at 08:01 GMT

Thank you for your comment. Your suggested general equation is correct. Our equation is valid from orthogonal estimates, which are the ones we suggest to obtain from the data in the paper.

No competing interests declared.