Advertisement
Research Article

A Negative Feedback Loop That Limits the Ectopic Activation of a Cell Type–Specific Sporulation Sigma Factor of Bacillus subtilis

  • Mónica Serrano,

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

    X
  • Gonçalo Real equal contributor,

    equal contributor Contributed equally to this work with: Gonçalo Real, Joana Santos

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

    X
  • Joana Santos equal contributor,

    equal contributor Contributed equally to this work with: Gonçalo Real, Joana Santos

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

    Current address: Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Australia

    X
  • Jorge Carneiro,

    Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal

    X
  • Charles P. Moran Jr.,

    Affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Adriano O. Henriques mail

    aoh@itqb.unl.pt

    Affiliation: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

    X
  • Published: September 15, 2011
  • DOI: 10.1371/journal.pgen.1002220

Reader Comments (7)

Post a new comment on this article

YabK

Posted by ParisSpore on 03 Oct 2011 at 16:30 GMT

was shown to inhibit the activity of σF
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002220#article1.body1.sec3.sec5.p2

There is no direct experimental evidence that the "yabK" product (herein called Fin) is an inhibitor of sigma-F. Such a function has only been suggested in ref. 38. Experiments in which sigma-F activity is monitored in the presence of YabK/Fin failed to indicate any inhibition, whereas sigma-F is higly sensitive to SpoIIAB, or to Gin/CsfB when produced in its hybrid sigma-GF form (ref. 28 and my own unpublished results). The Fin designation (contrarily to Gin) seems premature and potentially misleading.

No competing interests declared.