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Research Article

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

  • Anthony Arnoldo,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Jasna Curak,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Saranya Kittanakom,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Igor Chevelev,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Vincent T. Lee,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mehdi Sahebol-Amri,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Becky Koscik,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Lana Ljuma,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Peter J. Roy,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Antonio Bedalov,

    Affiliation: Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Guri Giaever,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada, Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada

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  • Corey Nislow,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada, Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada

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  • Rod A. Merrill,

    Affiliation: Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada

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  • Stephen Lory,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Igor Stagljar mail

    igor.stagljar@utoronto.ca

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Ontario, Canada

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  • Published: February 29, 2008
  • DOI: 10.1371/journal.pgen.1000005

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Publisher's Note: Correction to sub-headline

Posted by ploswebmaster on 02 Apr 2008 at 19:32 GMT

Yeast Growth Inhibition Is Mediated by Exoa and Exos ADPRT, and Exoy Adenylate Cyclase Activities
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000005#article1.body1.sec2.sec2.p1

The sub-headline "Yeast Growth Inhibition is Mediated by Exoa and Exos ADPRT, and Exoy Adenylate Cyclase Activities" should read: "Yeast Growth Inhibition is Mediated by ExoA and ExoS ADPRT, and ExoY Adenylate Cyclase Activities".