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Research Article

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

  • Adam C. Naj,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Gary W. Beecham,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eden R. Martin,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Paul J. Gallins,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eric H. Powell,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Ioanna Konidari,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Patrice L. Whitehead,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Guiqing Cai,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Vahram Haroutunian,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • William K. Scott,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jeffery M. Vance,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Michael A. Slifer,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Harry E. Gwirtsman,

    Affiliation: Veterans Affairs Medical Center, Nashville, Tennessee, United States of America

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  • John R. Gilbert,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jonathan L. Haines equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Joseph D. Buxbaum equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Margaret A. Pericak-Vance equal contributor mail

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    mpericak@med.miami.edu

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.pgen.1001130

Reader Comments (3)

Post a new comment on this article

Late onset Alzheimer and genes

Posted by jedsrose on 28 Sep 2010 at 15:08 GMT

To link wide genomic association of sequences to any Late-Onset Disease can be a quite risky endeavour. However, this work seems to have done it carefully and with the support of metabolic changes that allows for sound interpretation of the findings. Other associations, een when pseudo-genes are not involved, do not present a clear separation of sequence changes that may represent noise from those that indicate sound medical signals.

No competing interests declared.

RE: Late onset Alzheimer and genes

jedsrose replied to jedsrose on 28 Sep 2010 at 15:13 GMT

Sorry, the correct typing should be: even when pseudo-genes are not.....

No competing interests declared.