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Research Article

Tissue Effect on Genetic Control of Transcript Isoform Variation

  • Tony Kwan equal contributor mail,

    equal contributor Contributed equally to this work with: Tony Kwan, Elin Grundberg

    tony.kwan@mcgill.ca

    Affiliations: Department of Human Genetics, McGill University, Montréal, Canada, McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Elin Grundberg equal contributor,

    equal contributor Contributed equally to this work with: Tony Kwan, Elin Grundberg

    Affiliations: Department of Human Genetics, McGill University, Montréal, Canada, McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Vonda Koka,

    Affiliation: McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Bing Ge,

    Affiliation: McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Kevin C. L. Lam,

    Affiliation: McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Christel Dias,

    Affiliation: McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Andreas Kindmark,

    Affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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  • Hans Mallmin,

    Affiliation: Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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  • Östen Ljunggren,

    Affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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  • Fernando Rivadeneira,

    Affiliations: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

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  • Karol Estrada,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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  • Joyce B. van Meurs,

    Affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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  • Andre Uitterlinden,

    Affiliations: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

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  • Magnus Karlsson,

    Affiliation: Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Science, Lund University and Department of Orthopaedics, Malmö University Hospital, Malmö, Sweden

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  • Claes Ohlsson,

    Affiliation: Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg University, Gothenburg, Sweden

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  • Dan Mellström,

    Affiliation: Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg University, Gothenburg, Sweden

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  • Olle Nilsson,

    Affiliation: Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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  • Tomi Pastinen,

    Affiliations: Department of Human Genetics, McGill University, Montréal, Canada, McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Jacek Majewski

    Affiliations: Department of Human Genetics, McGill University, Montréal, Canada, McGill University and Genome Québec Innovation Centre, Montréal, Canada

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  • Published: August 14, 2009
  • DOI: 10.1371/journal.pgen.1000608

Reader Comments (1)

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Isoforms ratio

Posted by Leonid on 15 Aug 2009 at 08:59 GMT

genetic control may affect the relative expression of one isoform to another, rather than having an all-or-none effect
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000608#article1.front1.article-meta1.abstract1.p1

This will be crucial for understanding of association of genetic variants with human complex diseases, like rheumatoid arthritis, asthma, etc. An example of the shift in such ratio for IL-4 receptor expression in different genetic context was shown previously by Bergin et al., 2006 (Human Mutation).

No competing interests declared.