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Research Article

Requirements for F-BAR Proteins TOCA-1 and TOCA-2 in Actin Dynamics and Membrane Trafficking during Caenorhabditis elegans Oocyte Growth and Embryonic Epidermal Morphogenesis

  • Chiara Giuliani equal contributor,

    equal contributor Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Flavia Troglio equal contributor,

    equal contributor Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

    X
  • Zhiyong Bai equal contributor,

    equal contributor Contributed equally to this work with: Chiara Giuliani, Flavia Troglio, Zhiyong Bai

    Affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

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  • Falshruti B. Patel,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry New Jersey—Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

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  • Adriana Zucconi,

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Maria Grazia Malabarba,

    Affiliations: The FIRC Institute for Molecular Oncology, Milan, Italy, University of Milan Medical School, Milan, Italy

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  • Andrea Disanza,

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Theresia B. Stradal,

    Affiliations: Signalling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig, Germany, University of Bonn, Bonn, Germany

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  • Giuseppe Cassata,

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Stefano Confalonieri,

    Affiliation: The FIRC Institute for Molecular Oncology, Milan, Italy

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  • Jeffrey D. Hardin,

    Affiliation: Department of Zoology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Martha C. Soto,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry New Jersey—Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

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  • Barth D. Grant mail,

    Giorgio.scita@ifom-ieo-campus.it (GS); grant@dls.rutgers.edu (BDG)

    Affiliation: Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America

    These authors contributed equally to this work.

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  • Giorgio Scita mail

    Giorgio.scita@ifom-ieo-campus.it (GS); grant@dls.rutgers.edu (BDG)

    Affiliations: The FIRC Institute for Molecular Oncology, Milan, Italy, University of Milan Medical School, Milan, Italy

    These authors contributed equally to this work.

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  • Published: October 02, 2009
  • DOI: 10.1371/journal.pgen.1000675

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Acknowledgments

Posted by cgiulian on 05 Oct 2009 at 13:36 GMT

We thank Dr. Shohei Mitani and the National BioResource Project for C. elegans (Japan) for generating tm2056, tm3334, and tm2088. Some nematode strains used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources (NCRR). We thank Holger Kloess for technical help. We also thank Dr. Gian Garriga and Dr. Shiro Suetsugu for WSP-1 antibody
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000675#article1.back1.ack1.p1

We thank Dr. Ronen Zaidel-Bar for generating some of the critical reagents used to characterize the role of tocas in embryonic development.

No competing interests declared.