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Research Article

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

  • Ying Liu,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Cynthia Helms,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Wilson Liao,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Lisa C. Zaba,

    Affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

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  • Shenghui Duan,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jennifer Gardner,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Carol Wise,

    Affiliation: Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, United States of America

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  • Andrew Miner,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • M. J. Malloy,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Clive R. Pullinger,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • John P. Kane,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Scott Saccone,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jane Worthington,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Ian Bruce,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Pui–Yan Kwok,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Alan Menter,

    Affiliation: Department of Internal Medicine, Division of Dermatology, Baylor University Medical Center, Dallas, Texas, United States of America

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  • James Krueger,

    Affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

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  • Anne Barton,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Nancy L. Saccone,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Anne M. Bowcock mail

    bowcock@genetics.wustl.edu

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: April 04, 2008
  • DOI: 10.1371/journal.pgen.1000041

Reader Comments (1)

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IL-21 genetic association with SLE

Posted by asawalha on 18 Apr 2008 at 03:42 GMT

I would like to congratulate the authors for a nice study and report. However, the authors failed to mention that the genetic region harboring IL-21 on chromosome 4q27 has been previously associated with systemic lupus erythematosus (1). Indeed, the association between SNPs within IL-21 and lupus was published online first in August, 2007, prior to the report describing the association of this same region in rheumatoid arthritis. The fact that this locus is associated with multiple autoimmune diseases suggests that functional characterization of this polymorphism might provide important information pertinent to a common pathway in the origin of autoimmunity.

(1) Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DR, James JA, Merrill JT, Lipsky P, Harley JB. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus.
Ann Rheum Dis. 2008 Apr;67(4):458-61. Epub 2007 Aug 24.


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Amr H Sawalha, MD
Assistant Professor
University of Oklahoma Health Sciences Center
US Department of Veterans Affairs
Oklahoma Medical Research Foundation